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Over the last decade, three large-scale projects have catalyzed a revolution in genetic technologies and studies. First, the Human Genome Project laid the foundation for modern genetic studies of disease by determining the basic sequence of the 3 billion building blocks (i.e., base pairs) that make up the human genome and by identifying the approximately 25,000 genes included in this sequence (htt...

Circadian Disruption and Society

The circadian clock is a sophisticated mechanism that functions to synchronize (i.e., entrain) endogenous systems with the 24-hour day in a wide variety of organisms, from simple organisms such as fungi up to the complex mammalian systems. Circadian rhythms control a variety of biological processes, including sleep/wake cycles, body temperature, hormone secretion...

In large amounts, alcohol and its metabolites can overwhelm the gastrointestinal tract (GI) and liver and lead to damage both within the GI and in other organs. Specifically, alcohol and its metabolites promote intestinal inflammation through multiple pathways. That inflammatory response, in turn, exacerbates alcohol-induced organ damage, creating a vicious cycle and leading to additional...

The duration and extent of the body’s exposure to beverage alcohol (i.e., ethanol) is the primary determinant of ethanol’s pleiotropic effects on human health (Edenberg 2007). The time course of its concentration and the concentration of its byproducts in the tissues and the circulation, and, consequently, its effects, are determined mainly by the rate of ethanol’s processing (i.e., metabolism) in...

NIAAA/NIH Staff

Pamela Wernett, Ph.D., P.M.P.
Editor in Chief and Contracting Officer’s Representative

Pamela joined ARCR in 2018 as an Associate Editor and advanced to Editor in Chief for the journal in 2021. She has managed the journal contract with IQ Solutions as the Contracting Officer’s Representative since 2020. Pamela also serves as a Senior Health Science Policy Analyst within NIAAA’s...

Even though the prevalence of alcohol use in the United States generally is lower among women compared with men (Substance Abuse and Mental Health Services Administration [SAMHSA] 2011), this gap has narrowed (Grucza et al. 2008). Furthermore, although women consume alcohol at lower levels than men, their body composition puts them at higher risk than men of developing some alcohol-related...

The association between alcohol misuse and organ damage, specifically liver disease, has been recognized for more than 200 years (Maher 1997). Yet it was not until the early 1970s that researchers demonstrated a direct causal relationship between drinking and this serious—and sometimes fatal—condition.

This issue of Alcohol Research: Current Reviews examines the public health impact of alcohol consumption beyond the role of alcohol use disorders alone (Room et al. 2005)—that is, it looks at the burden of disease. Determining impact hinges on accurate and consistent “measurements.” As demonstrated in the articles in this issue, impact typically is estimated based on three elements (Rehm et al...

The concept that only DNA and proteins can impact disease states is an oversimplification. It does not take into account different metabolic pathways in which key metabolites bind to transcription factors and alter gene expression patterns that contribute to the observable characteristics (the phenotype) of a given disease. Simple metabolites dictate the actions of specific transcription factors...